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GLI3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 19949-1-AP-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16839424

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

The antibody is specific to GLI3. At the molecular level, Gli3 is translated into a 190 kDa transcriptional activator (Gli3-190) that undergoes proteolytic processing into a truncated 83 kDa repressor (Gli3-83) lacking C-terminal activation domains.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.
Spezifikation

Spezifikation

GLI3
Polyclonal
Unconjugated
GLI3
ACLS, GCPS, GLI family zinc finger 3, GLI3, PAP A, PAPA, PAPA1, PAPB, PHS, PPDIV, Zinc finger protein GLI3
Rabbit
Antigen Affinity Chromatography
RUO
140588, 14634, 2737
Antibody
IgG
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence
0.24 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P10071, Q61602
Gli3
Peptide
20 μL
Primary
Rat, Mouse, Human
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote