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FOXO1 Mouse anti-Human, Clone: 1D9A2, Proteintech
Mouse Monoclonal Antibody
133.80 CHF - 381.34 CHF
Spezifikation
Antigen | FOXO1 |
---|---|
Klon | 1D9A2 |
Konzentration | 1 mg/mL |
Anwendungen | Western Blot |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
16838355
|
Proteintech
66457-1-IG-20UL |
20 μL |
133.80 CHF
20 Mikroliter |
Verfügbar ab: 14-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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16828355
|
Proteintech
66457-1-IG-150UL |
150 μL |
381.34 CHF
150 Mikroliter |
Verfügbar ab: 14-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors. Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein. Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma. Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation. FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress. FOXO1 binds to the insulin response element (IRE) with consensus sequence 5′-TT[G/A]TTTTG-3′ and the related Daf-16 family binding element (DBE) with consensus sequence 5′- TT[G/A]TTTAC-3′. FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass. Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.Spezifikation
FOXO1 | |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
FKH1, FKHR, forkhead box O1, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1, FOXO1A | |
FOXO1 | |
IgG1 | |
Protein G | |
Antibody |
1D9A2 | |
Western Blot | |
Unconjugated | |
Mouse | |
Human | |
Q12778 | |
2308 | |
FOXO1 Fusion Protein ag13296 | |
Primary | |
-20°C | |
FOXO1 |