FOXM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Beschreibung

Product No. 13147-1-AP is rabbit polyclonal antibody raised against C-terminal of human FOXM1. This antibody can recognize three kinds of FOXM1,FOXM1-pp (∽95-110 kDa), FOXM1-B (isoform2,∽83 kDa) and FOXM1A (isoform4, ∽90 kDa)

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.