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Invitrogen™ Factor X/Xa Monoclonal Antibody (5051)
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Artikelnummer. 11529862
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Menge:
100 μg
Packungsgröße:
100 Mikrogramm
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11529862 100 μg 100 Mikrogramm
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Artikelnummer. 11529862 Lieferant Invitrogen™ Lieferanten-Nr. MA143014

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Beschreibung

Mouse Monoclonal Antibody

This antibody detects the heavy chain of bovine Factor X and Xa, BEGRck factor Xa. It will cross-react with human, rabbit, sheep, porcine and canine factor X. This antibody does not recognize murine Factor X via Western blot. Inhibitory properties: inhibitory in clotting assay (APTT and PT), partial calcium dependence. Dissociation Constant: Kd = 9X10^(-11)M. Purity >95% by SDS-PAGE.

Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
TRUSTED_SUSTAINABILITY

Spezifikation

Antigen Factor X/Xa
Anwendungen Affinity Purification, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
Klassifikation Monoclonal
Klon 5051
Konzentration 8.4 mg/mL
Konjugat Unconjugated
Zusammensetzung 50% water with 50% glycerol and no preservative
Gen F10
Gen-Zugriffsnummer O19045, P00742, P00743
Gen-Alias Activated factor Xa heavy chain; blood coagulation factor X; Cf10; coagulation factor 10; coagulation factor X; coagulation factor X protein; F10; Factor X heavy chain; Factor X light chain; factor Xa; FX; FXA; prothrombinase; stuart factor; Stuart-Prower factor; Unknown (protein for IMAGE:8121240); unnamed protein product
Gensymbole F10
Wirtsspezies Mouse
Immunogen Purified bovine Factor X.
Reinigungsverfahren SDS-PAGE
Menge 100 μg
Regulatorischer Status RUO
Primär oder sekundär Primary
Gen-ID (Entrez) 100008647, 101118624, 2159, 280787, 476993, 733662
Zielspezies Human, Canine, Rabbit, Bovine, Sheep, Pig
Inhalt und Lagerung -20°C, Avoid Freeze/Thaw Cycles
Produkttyp Antibody
Form Liquid
Isotype IgG1
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