Invitrogen™ EYA1 Polyclonal Antibody

Beschreibung

Immunogen sequence: SQSPGQTGFLS YGTSFSTPQP GQAPYSYQMQ GSSFTTSSGI YTGNNSLTNS SGFNSSQQDY PSYPSFGQGQ YAQYYNSSPY PAHYMTSSNT SPTTPSTNAT YQLQEPPSGI TSQAVTDPTA EYSTIHSPST PIKDSDSDRL RRGSD Highest antigen sequence identity to the following orthologs - mouse 95%, rat 97%.

This gene encodes a member of the eyes absent family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.