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ACROBiosystems Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) Envelope Glycoprotein 1 (GP1) Protein, His Tag

Marke:  ACROBiosystems ZE5-V5220-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15817957

  • 299.38 CHF / 100 Mikrogramm


Verfügbar ab
28-05-2021
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Beschreibung

Beschreibung

EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.0 kDa. The protein migrates as 95-120 kDa under reducing (R) condition (SDS-PAGE).
Spezifikation

Spezifikation

AAQ55048.1
HEK293
Ebolavirus
52.0 kDa
100 µg
Ile 33 - Arg 501
GP,Envelope glycoprotein,GP(1,2)
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Viral Proteins
Powder
>95% as determined by SDS-PAGE
Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) GP1, His Tag (ZE5-V5220) is expressed from human 293 cells (HEK293). It contains AA Ile 33 - Arg 501 (Accession # AAQ55048.1).
-20°C
Glycoprotein / GP (virus)
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation