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E-cadherin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
133.80 CHF - 381.34 CHF
Spezifikation
Antigen | E-cadherin |
---|---|
Konzentration | 0.34 mg/mL |
Anwendungen | Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation |
Klassifikation | Polyclonal |
Konjugat | Unconjugated |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
16850455
|
Proteintech
20874-1-AP-20UL |
20 μL |
133.80 CHF
20 Mikroliter |
Verfügbar ab: 07-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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16840455
|
Proteintech
20874-1-AP-150UL |
150 μL |
381.34 CHF
150 Mikroliter |
Verfügbar ab: 07-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
This polyclonal antibody recognizes 120 kDa intact E-cadherin and its 80 kDa trypsin-cleaved fragment.
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintece of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.Spezifikation
E-cadherin | |
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation | |
Unconjugated | |
Rabbit | |
Human, Mouse, Rat | |
P09803, P12830, Q9R0T4 | |
12550, 83502, 999 | |
E-cadherin Fusion Protein Ag14973 | |
Primary | |
-20°C | |
CDH1 |
0.34 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin | |
Cdh1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |