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  5. Tocris Bioscience™ DREADD agonist 21

Tocris Bioscience™ DREADD agonist 21

Artikelnummer. 18025422
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Menge:
10 mg
50 mg
Packungsgröße:
10 Milligramm
50 Milligramm
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Artikelnummer. 18025422

Marke: Tocris Bioscience™ 5548/10

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Description

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

DREADD agonist 21 is a potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits > 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo. Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).
TRUSTED_SUSTAINABILITY

Specifications

Chemischer Name oder Material 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
CAS 56296-18-5
Menge 10 mg
Ziel DREADD Activators
Summenformel C17H18N4
Reinheit 0.98
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