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DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
Marke: Affymetrix eBioscience 16-5948-050
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Beschreibung
This HMD4-1 MAb reacts with the extracellular domain of mouse Delta-like 4, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g., Notch 1-4), Delta-like 4 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Delta-like 4 is expressed by thymic lymphoid and stromal cells, as well as macrophages and dendritic cells in the spleen. This molecule is also expressed in non-immune cells, including vascular smooth muscle and endothelial cells. Delta-like 4 plays a role in T cell development, regulation of experimental autoimmune encephalomyelitis, and the formation of mature vasculature. The HMD4-1 MAb has been reported to have blocking activity and crossreact to rat.
DLL4 (delta-like 4) Monoclonal antibody specifically detects DLL4 (delta-like 4) in Mouse, Rat samples. It is validated for Functional Assay
Spezifikation
| DLL4 (delta-like 4) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| D3ZHH1, Q9JI71 | |
| Armenian Hamster | |
| 50 mg | |
| Primary | |
| Mouse, Rat | |
| Antibody | |
| IgG |
| Functional Assay | |
| HMD4-1 | |
| Functional Grade | |
| Dll4 | |
| AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341 | |
| Affinity chromatography | |
| RUO | |
| 311332, 54485 | |
| 4° C | |
| Liquid |
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Name des Produkts
DLL4 (delta-like 4) Monoclonal Antibody (HMD4-1), Functional Grade, eBioscience™, Invitrogen™ > 50 mg; Functional Grade
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