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Diclofenac sodium salt
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52.75 CHF
47.65 CHF / 5 Gramm
Sparen 5.10 CHF
9% Rabatt
Descripción
Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.
Solubility
Soluble in water (50 mg/ml), PBS pH 7.2 (6 mg/ml), ethanol (∼35 mg/ml), DMF (∼35 mg/ml), DMSO (∼35 mg/ml), methanol (>24 mg/ml), and acetone (6 mg/ml).
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
Especificaciones
Especificaciones
| Chemischer Name oder Material | Diclofenac sodium salt |
| Schmelzpunkt | 283°C to 285°C |
| Farbe | Weiß |
| Menge | 5 g |
| UN-Nummer | UN2811 |
| Merck Index | 14,3081 |
| Löslichkeitsinformationen | Soluble in water to 50mg/ml. |
| Formelmasse | 318.14 |
| Physikalische Form | Pulver |
Seguridad y manipulación
- Diclofenac sodium salt
- Gefahr
- Akute Toxizität Kategorie 3
- H301-Giftig bei Verschlucken.
- P301+P310-BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt anrufen
- MIXTURE LIST-Contain: Diclofenac sodium salt
RUO – Research Use Only
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