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DELE Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Thermo Scientific PA557712
Additional Details : Gewicht : 0.02000kg
Beschreibung
Immunogen sequence: PLDRFFSSPL WHPCSSLRQH ILPSPDGPAP RHTGLREPRL GQEEASAQPR NFSHNSLRGA RPQDPSEEGP GDFGFLHASS SIESEAKPAQ P Highest antigen sequence identity to the following orthologs: Mouse - 55%, Rat - 59%.
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.Spezifikation
DELE | |
Polyclonal | |
Unconjugated | |
KIAA0141 | |
DELE, Death ligand signal enhancer, KIAA0141 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
9812 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q14154 | |
KIAA0141 | |
Recombit protein corresponding to Human DELE | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only