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ACROBiosystems Cynomolgus TIM-3 / HAVCR2 Protein, Fc Tag

400.19 CHF - 2913.85 CHF

Spezifikation

Zugriffsnummer EHH54703.1
Molekulargewicht 45.8 kDa
Quelle Cynomolgus TIM-3, Fc Tag (TI3-C525b) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 201 (Accession # EHH54703.1).
Immunogen Ser 22 - Arg 201
Lagerungsbedingungen -20°C
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15827767
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ACROBiosystems
TI3-C525B-100UG
100 μg
400.19 CHF
100 Mikrogramm
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15837767
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ACROBiosystems
TI3-C525B-1MG
1 mg
2913.85 CHF
1 Milligramm
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Verfügbar ab: 10-04-2024
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Beschreibung

Beschreibung

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.8 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

EHH54703.1
Cynomolgus TIM-3, Fc Tag (TI3-C525b) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 201 (Accession # EHH54703.1).
-20°C
TIM-3
Cynomolgus Monkey
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Immune Checkpoint Proteins
45.8 kDa
Ser 22 - Arg 201
HAVCR2,TIM3,TIMD3,FLJ14428,KIM3
Unconjugated
Fc Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>85% as determined by SDS-PAGE
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Sicherheitsdatenblatt (SDS)
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