Learn More
ACROBiosystems Cynomolgus CD3 delta Protein, His Tag
Marke: ACROBiosystems CDD-C52H8-100UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.3 kDa. The protein migrates as 26-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
14.3 kDa | |
Cynomolgus CD3 delta, His Tag (CDD-C52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Ala 105 (Accession # Q95LI8). | |
-20°C | |
CD3 delta | |
Cynomolgus Monkey | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |
100 μg | |
Phe 22 - Ala 105 | |
CD3D,CD3-DELTA,T3D | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |