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ACROBiosystems Cynomolgus CD3 delta Protein, His Tag

Marke:  ACROBiosystems CDD-C52H8-100UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826377

  • 362.71 CHF / 100 Mikrogramm


Verfügbar ab
27-05-2021
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Beschreibung

Beschreibung

CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.3 kDa. The protein migrates as 26-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>90% as determined by SDS-PAGE
Cynomolgus CD3 delta, His Tag (CDD-C52H8) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Ala 105 (Accession # Q95LI8).
-20°C
CD3 delta
His Tag
HEK293
Cynomolgus
14.3 kDa
100 µg
Phe 22 - Ala 105
CD3D,CD3-DELTA,T3D
Unconjugated
PBS, pH7.4
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation