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CRACR2A Mouse anti-Human, Clone: 4C1F5, Proteintech

Mouse Monoclonal Antibody

Marke:  Proteintech 66787-1-IG-150UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838985

  • 351.68 CHF / 150 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

This antibody recognizes both of CRACR2A-c and CRACR2A-a.

CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Spezifikation

Spezifikation

CRACR2A
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9BSW2
CRACR2A
CRACR2A Fusion Protein Ag7525
150 μL
Primary
Human
Liquid
Western Blot
4C1F5
Unconjugated
CRACR2A
CRAC channel regulator 2A, CRACR2A, DKFZp686G13246, EFCAB4B, FLJ33046, FLJ33805
Mouse
Protein G
RUO
84766
Antibody
IgG1
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