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CRACR2A Mouse anti-Human, Clone: 4C1F5, Proteintech
Mouse Monoclonal Antibody
Marke: Proteintech 66787-1-IG-150UL
Additional Details : Gewicht : 0.00010kg
Beschreibung
This antibody recognizes both of CRACR2A-c and CRACR2A-a.
CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.Spezifikation
CRACR2A | |
Monoclonal | |
1 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q9BSW2 | |
CRACR2A | |
CRACR2A Fusion Protein Ag7525 | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Western Blot | |
4C1F5 | |
Unconjugated | |
CRACR2A | |
CRAC channel regulator 2A, CRACR2A, DKFZp686G13246, EFCAB4B, FLJ33046, FLJ33805 | |
Mouse | |
Protein G | |
RUO | |
84766 | |
-20°C | |
Liquid |