Invitrogen™ COL7A1 Polyclonal Antibody

Beschreibung

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: LTLYTLLEGH EVATPATVVP TGPELPVSPV TDLQATELPG QRVRVSWSPV PGATQYRIIV RSTQGVERTL VLPGSQTAFD LDDVQAGLSY TVRVSARVGP REGSASVLTV RREPETPLAV PGLRVVVSDA TRVRVAWGPA PGASGFRI.

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008].