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CD8 Mouse anti-Human, PE-Cy5, Clone: RPA-T8, BD

Mouse Monoclonal Antibody

237.00 CHF - 615.00 CHF

Spezifikation

Antigen CD8
Klon RPA-T8
Anwendungen Flow Cytometry
Klassifikation Monoclonal
Konjugat PE-Cyanine5
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15861499
Unterlagen ansehen Aktionsdetails
BD Biosciences
561951
25 Tests
237.00 CHF
1 Stück
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Verfügbar ab: 23-04-2024
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15828108
Unterlagen ansehen Aktionsdetails
BD Biosciences
555368
100 Tests
615.00 CHF
1 Stück
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 16-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8α) . CD8α is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8α is expressed by the majority of thymocytes, by subpopulations of αβ T cells and γδ T cells and by some NK cells. Cell surface CD8α is expressed either as a disulfide-linked homodimer (CD8αα) αβ T cells coexpress both CD8αα homodimers and CD8αβ heterodimers whereas some γδ T cells and NK cells express CD8αα homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8 α binds to a non-polymorphic determinant on HLA class I molecules (α3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8α associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a monoclonal antibodies are not cross-blocking. This clone has been reported to react with a subset of peripheral blood lymphocytes, but not monocytes nor granuloyctes, of baboon and both rhesus and cynomolgus macaque monkey. In general, a higher frequency of CD8+ and CD4+CD8+ lymphocytes are observed in non-human primates compared to normal human donors.

Spezifikation

Spezifikation

CD8
Flow Cytometry
PE-Cyanine5
RUO
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
CD8α; CD8A; CD8 alpha; Leu2; MAL; T8; p32
RPA-T8
Monoclonal
Mouse
Baboon, Cynomolgus, Human, Rhesus Monkey
Human CD8a
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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For Research Use Only.