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CD73 Monoclonal Antibody (eBioTY/11.8 (TY/11.8)), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

99.00 CHF - 148.00 CHF

Spezifikation

Antigen CD73
Konzentration 0.5 mg/mL
Anwendungen Flow Cytometry, Immunohistochemistry
Klassifikation Monoclonal
Konjugat Unconjugated
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15267067
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
14-0731-81
50 μg
99.00 CHF
50 Mikrogramm
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Verfügbar ab: 07-05-2024
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15277067
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
14-0731-82
100 μg
148.00 CHF
100 Mikrogramm
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Lager vorrätig
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Description: eBioTY/11.8 recognizes the with CD73 a 69-kDa GPI-anchored cell-surface protein with ecto-5'-nucleotidase activity. Expression on myeloid cells (CD11b) is restricted to the bone marrow. In human CD73 can be induced to secrete a soluble form with IL-2 suggesting a role in mediating activation signals. Differences between human and mouse CD73 have been reported. BALB/c mice have more CD4+CD73+ than CD8+CD73+ while the reciprocal is documented in humans. CD73 is expressed on a subset of lymphocytes and increases during lymphocyte maturation. Recently it has been found that memory CD4 T cells express and are similar to the uncommitted primed precursor helper cells (Thpp) that can differentiate into Th1 or Th2 cells. Furthermore CD73 has been found on regulatory T cells. Applications Reported: This eBioTY/11.8 (TY/11.8) antibody has been reported for use in flow cytometric analysis, and immunohistochemical staining. Applications Tested: This eBioTY/11.8 (TY/11.8) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.06 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations. Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been found.
Spezifikation

Spezifikation

CD73
Flow Cytometry, Immunohistochemistry
Unconjugated
Rat
Mouse
23959
Primary
4° C
0.5 mg/mL
Monoclonal
Liquid
RUO
Q61503
IgG1
Affinity chromatography
Antibody
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Sicherheitsdatenblatt (SDS)
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