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CD73 Monoclonal Antibody (AD2), Super Bright™ 702, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
163.00 CHF - 376.00 CHF
Spezifikation
Antigen | CD73 |
---|---|
Klon | AD2 |
Konzentration | 5 μL/Test |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15973734
|
Affymetrix eBioscience
67-0739-42 |
100 Tests |
376.00 CHF
100 Stück |
Verfügbar ab: 16-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15963734
|
Affymetrix eBioscience
67-0739-41 |
25 Tests |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
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Beschreibung
Description: This AD2 monoclonal antibody reacts with human CD73, a 5'-ectonucleotidase that converts 5'-adenosine monophosphate to adenosine. CD73 is expressed on the surface of endothelial cells, as well as B and T cells, including some CD4+Foxp3+ regulatory T cells. Adenosine production by these cells has been linked to the inhibition of CD4 T cell effector functions such as proliferation and cytokine secretion.
CD73 (Ecto-5-prime-nucleotidase, 5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. CD73 consists of a dimer of 2 identical 70 kDa subunits bound externally to the plasma membrane by a glycosyl phosphatidyl inositol linkage. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of CD73 occurs in a variety of immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from CD73 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene has been localized to 6q14-q21 by immunofluorescence and a study of a panel of human x mouse hybrids that contained fragments of chromosome 6 as translocations. Defects in the CD73 gene can lead to the calcification of joints and arteries, and intestinal tuberculosis. Two transcript variants encoding different isoforms of CD73 have been found.Spezifikation
CD73 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P21589 | |
NT5E | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
NT5E |
AD2 | |
Flow Cytometry | |
Super Bright 702 | |
Mouse | |
Human | |
4907 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |