CD66a (CEACAM1) Mouse anti-Mouse, Clone: CC1, eBioscience™
Mouse Monoclonal Antibody
Marke: Affymetrix eBioscience 14-0661-80
Additional Details : Gewicht : 0.01000kg
BeschreibungIt is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregcy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
|PBS with 0.09% sodium azide; pH 7.2|
|BGP, BGP1, BGPI, CD66a antigen, antigen CD66, carcinoembryonic antigen-related cell adhesion molecule 1|
|Flow Cytometry, Functional Assay, Immunohistochemistry (Paraffin), Western Blot|
For Research Use Only.