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CD54 (ICAM-1) Monoclonal Antibody (YN1/1.7.4), FITC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

114.00 CHF - 385.00 CHF

Spezifikation

Antigen CD54 (ICAM-1)
Klon YN1/1.7.4
Konzentration 0.5 mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 3
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15238119
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Affymetrix eBioscience
11-0541-81
50 μg
114.00 CHF
50 Mikrogramm
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Verfügbar ab: 07-05-2024
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15248119
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Affymetrix eBioscience
11-0541-82
100 μg
215.00 CHF
100 Mikrogramm
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15258119
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Affymetrix eBioscience
11-0541-85
500 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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Beschreibung

Beschreibung

Description: The YN1/1.7.4 monoclonal antibody reacts with mouse CD54 (InterCellular Adhesion Molecule-1, ICAM-1), a 90-110 kDa transmembrane glycoprotein expressed by monocytes, lymphocytes, dendritic cells, and endothelial cells. Expression of CD54 is upregulated on activated lymphocytes. Interaction of CD54 with its ligands CD11a and CD11b is important in the inflammatory response. The YN1/1.7.4 monoclonal antibody recognizes a different epitope than the eBioKAT-1 monclonal antibody. Applications Reported: The YN1/1.7.4 antibody has been reported for use in flow cytometric analysis. Applications Tested: The YN1/1.7.4 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.
Spezifikation

Spezifikation

CD54 (ICAM-1)
0.5 mg/mL
Monoclonal
Liquid
RUO
P13597
IgG2b κ
Affinity chromatography
Antibody
YN1/1.7.4
Flow Cytometry
FITC
Rat
Mouse
15894
Primary
4° C, store in dark, DO NOT FREEZE!
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