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CD45RO Mouse anti-Human, Super Bright 702, Clone: UCHL1, eBioscience™

Mouse Monoclonal Antibody

Marke:  Invitrogen 67-0457-41

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15983724

  • 163.00 CHF / 25 Stück


Verfügbar ab
08-10-2020
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Beschreibung

Beschreibung

Fixation: Samples can be stored in IC Fixation Buffer (Product No. 00-8222) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product No. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 405 nm; Emission: 702 nm; Laser: Violet Laser Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company. CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Spezifikation

Spezifikation

CD45RO
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P08575
PTPRC
IgG2a, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
5788
Flow Cytometry
UCHL1
Super Bright 702
PTPRC
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
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