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CD45R/B220 Rat anti-Mouse, PE-CF594, Clone: RA3-6B2, BD

Rat Monoclonal Antibody

259.00 CHF - 670.00 CHF

Spezifikation

Antigen CD45R
Klon RA3-6B2
Konzentration 0.2mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15851809
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BD Biosciences
562313
25 μg
259.00 CHF
1 Stück
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Verfügbar ab: 23-04-2024
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15821789
Unterlagen ansehen Aktionsdetails
BD Biosciences
562290
0.1 mg
670.00 CHF
1 Stück
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Verfügbar ab: 16-04-2024
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Beschreibung

Beschreibung

The rat anti-mouse CD45R antibody (clone RA3-6B2) has been reported to react with an epitope on the extracellular domain of the transmembrane CD45 glycoprotein which is dependent upon the expression of exon A and specific carbohydrate residues. It is expressed on B lymphocytes at all stages from pro-B through mature and activated B cell, but it is decreased on plasma cells and a subset of memory B cells. The levels of CD45R expression on the B-cell lineage appear to be developmentally regulated. It is also reportedly found on the abnormal T cells involved in the lymphadenopathy of lpr/lpr and gld/gld mutant mice, on lytically active subsets of lymphokine-activated killer cells (NK cells and non-MHC-restricted CTL), on apoptotic T lymphocytes of mice injected with bacterial superantigen, on a population of NK-cell precursors in the bone marrow, and on B-lymphocyte, T-lymphocyte, and macrophage progenitors in fetal liver. The CD45R antigen has been reported not to be on hematopoietic stem cells, naive T lymphocytes, or MHC-restricted CTL. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. CD45R is commonly used as a pan B-cell marker; however, CD19 expression, detectable by the rat anti-mouse CD19 antibody (clone 1D3), is reported to be more restricted to the B-cell lineage. The rat anti-mouse CD45R antibody (clone RA3-6B2) has been reported to enhance isotype switching during in vitro B-cell responses and to inhibit in vivo B-cell responses. Cross-reaction of the RA3-6B2 clone with activated human T lymphocytes has also been reportedly observed.

This antibody is conjugated to BD Horizon™ PE-CF594, which has been developed exclusively by BD Biosciences as a better alternative to PE-Texas Red. PE-CF594 excites and emits at similar wavelengths to PE-Texas Red yet exhibits improved brightness and spectral characteristics. Due to PE having maximal absorption peaks at 496nm and 564nm, PE-CF594 can be excited by the blue (488-nm), green (532-nm) and yellow-green (561-nm) lasers and can be detected with the same filter set as PE-Texas Red (eg 610/20-nm filter).

Spezifikation

Spezifikation

CD45R
0.2mg/mL
Monoclonal
Rat
Mouse
Mouse Abelson Leukemia Virus-Induced pre-B tumor cells
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
RA3-6B2
Flow Cytometry
PE-CF594
RUO
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
B220; Ly-5; CD45R; LCA; Ptprc; Protein tyrosine phosphatase receptor type C
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.