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CD45, TRI-COLOR, clone: HI30, Invitrogen™

Mouse Monoclonal Antibody

Marke:  Invitrogen MHCD4506

Additional Details : Gewicht : 0.50000kg

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Artikelnummer. 10058202

  • 560.00 CHF / 1 Stück

Verfügbar ab: 08-07-2022
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Beschreibung

Beschreibung

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

The TRI-COLOR™ conjugate is a tandem R-phycoerythrin (PE)-Cy5™ conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
Spezifikation

Spezifikation

CD45
Monoclonal
TRI-COLOR
PTPRC
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C
Mouse
Purified
ASR, ASR/IVD
5788
Antibody
IgG1
Flow Cytometry
HI30
PBS with BSA, sucrose and 0.1% sodium azide
P08575
PTPRC
CD45 antigen
0.5 mL
Primary
Human
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote