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CD45.2, Super Bright 645, clone: 104, eBioscience™

Mouse Monoclonal Antibody

Marke:  Invitrogen 64-0454-80

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15805663

  • 188.00 CHF / 25 Mikrogramm


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von Anbieter 08-05-2019
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Beschreibung

Beschreibung

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Protect this vial and stained samples from light. Fixation: Samples can be stored in IC Fixation Buffer (cat. 00-8222) (100 μL of cell sample + 100 μL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 405 nm; Emission: 645 nm; Laser: Violet Laser CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
Spezifikation

Spezifikation

CD45.2
Monoclonal
0.2 mg/mL
PBS with BSA and 0.09% sodium azide; pH 7.2
P06800
PTPRC
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
19264
Flow Cytometry
104
Super Bright 645
Ptprc
Liquid
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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