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CD366 (TIM3) Rat anti-Mouse, APC, Clone: RMT3-23, eBioscience™

Rat Monoclonal Antibody

Marke:  Invitrogen 17-5870-82

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15805363

  • 273.00 CHF / 100 Mikrogramm


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von Anbieter 11-07-2019
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Beschreibung

Beschreibung

This may be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Spezifikation

Spezifikation

CD366 (TIM3)
Monoclonal
0.2 μg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q8VIM0
Havcr2; TIM-3; Tim3; Timd3
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
RMT3-23
APC
Havcr2
Liquid
Havcr2
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
171285
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