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CD317 (BST2, PDCA-1) Monoclonal Antibody (eBio129c (129c)), PE, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

142.00 CHF - 437.00 CHF

Spezifikation

Antigen CD317 (BST2, PDCA-1)
Klon eBio129c (129c)
Konzentration 0.2 mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15288739
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Affymetrix eBioscience
12-3171-82
100 μg
437.00 CHF
100 Mikrogramm
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15278739
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
12-3171-81
50 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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Beschreibung

Beschreibung

Description: The eBio129c monoclonal antibody reacts with mouse PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naive mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predomitly expressed by IPCs in the naive mouse which represent sa very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by the antibody 120G8. The epitope recognized by eBio129c is distinct from eBio927; thus, the antibodies can be used to costain, purify and identify pDCs. Applications Reported: This eBio129c (129c) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBio129c (129c) antibody has been tested by flow cytometric analysis of SJL splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
Spezifikation

Spezifikation

CD317 (BST2, PDCA-1)
0.2 mg/mL
Monoclonal
Liquid
RUO
Q8R2Q8
Bst2
Primary
4° C, store in dark, DO NOT FREEZE!
Bst2
eBio129c (129c)
Flow Cytometry
PE
Rat
Mouse
69550
IgG2b κ
Affinity chromatography
Antibody
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.