Learn More
CD278 (ICOS) Monoclonal Antibody (ISA-3), Biotin, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
142.00 CHF - 437.00 CHF
Spezifikation
Antigen | CD278 (ICOS) |
---|---|
Klon | ISA-3 |
Konzentration | 0.5 mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15320130
|
Affymetrix eBioscience
13-9948-82 |
100 μg |
437.00 CHF
100 Mikrogramm |
Lager vorrätigLoggen Sie sich ein, um den Lagerbestand zu sehen
|
|||||
15310130
|
Affymetrix eBioscience
13-9948-80 |
25 μg |
Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11. |
||||||
Beschreibung
Description: The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. Human ICOS has a relative molecular mass of 55-60 kDa, composed of 27 kDa and 29 kDa chains. Human ICOS on activated T cells has potent costimulatory activity for T cell activation and is required for humoral immune responses, in particular for memory B cell and plasma cell generation. ICOS binds to its ligand, B7h/B7RP-1 expressed on activated APCs (antigen presenting cells) and on a number of inflamed peripheral tissues. Plate-bound ISA-3 is costimulatory for T cells and induces production of IL-4, IL-5, IL-10 and other cytokines, but not IL-2. ISA-3 has the same reactivity pattern and characteristics as F44. ISA-3 was generated against the human ICOS antigen. C398.4A, anti-mouse ICOS/H4 (cat. 14-9949-82), was shown to cross-react with human ICOS but binds to an epitope different from ISA-3. C398.4A stains activated cells brighter than ISA-3; however, it also exhibits higher staining of non-activated human peripheral blood or isolated PBMC. To achieve the brightest staining of ICOS on activated human T cells, please use 13-9948-82 or 12-9948-42 rather than 11-9948-42. Applications Reported: The ISA-3 antibody has been reported for use in flow cytometric analysis.
ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.Spezifikation
CD278 (ICOS) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q9Y6W8 | |
ICOS | |
Primary | |
4° C, do not freeze | |
ICOS |
ISA-3 | |
Flow Cytometry | |
Biotin | |
Mouse | |
Human | |
29851 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.