missing translation for 'onlineSavingsMsg'
Learn More

CD254 (RANK Ligand) Rat anti-Mouse, Biotin, Clone: IK22/5, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 13-5952-82

Additional Details : Gewicht : 0.25000kg

 Lernen Sie weitere Varianten dieses

Artikelnummer. 15229949

  • 299.00 CHF / 100 Mikrogramm


Verfügbar ab
15-07-2020
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregcy. Two alternatively spliced transcript variants have been found.
Spezifikation

Spezifikation

CD254 (RANK Ligand)
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
O35235
RP11-86N24.2, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCE
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
IK22/5
Biotin
Tnfsf11
Liquid
Tnfsf11
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
21943
Videos
Dokumentation

For Research Use Only.