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CD226 (DNAM-1) Monoclonal Antibody (10E5), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 16-2261-85

370.68 CHF gültig bis 2024-03-29
Benutzen Sie den Promotions-Code "21615" um Ihren Promotions-Preis zu erhalten.



Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15268597

  • 556.00 CHF / 500 Mikrogramm
Verfügbar ab: 08-05-2024
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Beschreibung

Beschreibung

Description: This 10E5 monoclonal antibody reacts with mouse CD226, which is also known as DNAX accessory molecule-1 (DNAM-1). CD226 is an adhesion molecule expressed primarily on T cells, including thymocytes. The highest levels of CD226 are found on naive CD8 T cells. Moreover, expression of CD226 is regulated differentially in CD4 T cells. Under certain culture conditions, CD226 can be upregulated in Th1 and downregulated in Th2 and Th0 cells. This cell surface receptor can also be detected on natural killer cells, some B cell subsets, monocytes, and platelets. Interaction with its ligands, the poliovirus receptor (CD155) and CD112, results in adhesion and cell signaling events that promote innate and adaptive immunity, including differentiation, survival, and cytotoxicity. The 10E5 monoclonal antibody has been reported to inhibit antigen-specific T cell proliferation and IFN-gamma production in vivo. Applications Reported: This 10E5 antibody has been reported for use in flow cytometric analysis and functional assays. Applications Tested: This 10E5 antibody has been tested by flow cytometric analysis of 3-day CD3/CD28-stimulated mouse splenocytes. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

DNAM 1 is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes.
Spezifikation

Spezifikation

CD226 (DNAM-1)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
Q8K4F0
Cd226
Affinity chromatography
RUO
225825
4° C
Liquid
Flow Cytometry, Functional Assay
10E5
Functional Grade
Cd226
adhesion glycoprotein; BC051526; Cd226; CD226 antigen; CD226 molecule; DNAM 1; DNAM1; DNAM-1; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; platelet and T-cell activation antigen 1; Pta1; T lineage-specific activation antigen 1 antigen; TLiSA1
Rat
500 μg
Primary
Mouse
Antibody
IgG2b κ
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.