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CD202b (TIE2) Monoclonal Antibody (TEK4), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

135.00 CHF - 580.00 CHF

Spezifikation

Antigen CD202b (TIE2)
Klon TEK4
Konzentration 0.5 mg/mL
Anwendungen Flow Cytometry
Klassifikation Monoclonal
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Produkte 3
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15289979
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Affymetrix eBioscience
13-5987-82
100 μg
286.00 CHF
100 Mikrogramm
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Verfügbar ab: 10-04-2024
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15279979
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
13-5987-81
50 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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15299979
Unterlagen ansehen Aktionsdetails
Affymetrix eBioscience
13-5987-85
500 μg Dieser Artikel wurde eingestellt und ist leider nicht mehr verfügbar. Sehen Sie sich das Produkt an, um alternative Produktvorschläge zu sehen oder kontaktieren Sie unseren Technischen Support unter 056 618 41 11.
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Beschreibung

Beschreibung

Description: The TEK4 monoclonal antibody reacts with mouse Tie-2, also known as CD202. A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. Long-term multilineage repopulating cells were detected in Tie-2^+, Lineage^-, c-Kit^+, Sca1^+ cells but not in Tie-2^-, Lineage^-, c-Kit^+, Sca1^+ cells. Applications Reported: The TEK4 antibody has been reported for use in flow cytometric analysis. Applications Tested: This TEK4 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
Spezifikation

Spezifikation

CD202b (TIE2)
0.5 mg/mL
Monoclonal
Liquid
RUO
Q02858
IgG1 κ
Affinity chromatography
Antibody
TEK4
Flow Cytometry
Biotin
Rat
Mouse
21687
Primary
4° C, store in dark, DO NOT FREEZE!
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Product Certifications

For Research Use Only.