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CD195 Mouse anti-Human, APC, Clone: 2D7/CCR5, BD

Mouse Monoclonal Antibody

276.00 CHF - 670.00 CHF

Spezifikation

Antigen CD195
Klon 2D7/CCR5
Anwendungen Flow Cytometry
Klassifikation Monoclonal
Konjugat APC
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15831299
Unterlagen ansehen Aktionsdetails
BD Biosciences
561748
25 Tests
276.00 CHF
1 Stück
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Verfügbar ab: 22-04-2024
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15818798
Unterlagen ansehen Aktionsdetails
BD Biosciences
556903
100 Tests
670.00 CHF
1 Stück
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 22-04-2024
Sie sich ein, um den Lagerbestand zu sehen
Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

The 2D7/CCR5 monoclonal antibody specifically binds to the human chemokine receptor, CCR5. CCR5 is also known as CD195. CCR5 is a seven transmembrane-spanning G protein-associated molecule. CCR5 belongs to the beta chemokine receptor family. It is expressed on a subset of T lymphocytes (CD3+CD45RO+CD95+). CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation. It signals a response to at least three chemokines: RANTES and macrophage inflammatory protein-1 (MIP-1), and monocyte chemoattractant protein 2 (MCP-2). Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission. Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection. This antibody has been shown to block ligand and gp120 binding. It is also able to neutralize HIV infection.

Spezifikation

Spezifikation

CD195
Flow Cytometry
APC
RUO
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
IgG2a κ
Affinity Purified
CCR5; C-C chemokine receptor type 5; CC-CKR-5; CKR5; CHEMR13
2D7/CCR5
Monoclonal
Mouse
Human
Human CCR5 Transfected Cell Line
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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