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CD185 (CXCR5) Mouse anti-Human, Non-human primate, Rhesus Monkey, Super Bright 436, Clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Marke:  Invitrogen 62-9185-42

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15983444

  • 315.00 CHF / 100 Stück


Verfügbar ab
08-10-2020
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Beschreibung

Beschreibung

A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. We recommend using a 450/50 bandpass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome. When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product No. SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information. Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company. CXCR5 (C-X-Chemokine Receptor Type 5, CD185) also known as Burkitt lymphoma receptor 1 (BLR1) belongs to the CXC chemokine receptor family. CXCR5 is a G protein-coupled seven transmembrane receptor for chemokine BLC. CXCR5 gene is specifically expressed in Burkitt′s lymphoma and lymphatic tissues, such as follicles in lymph nodes, as well as in spleen. Studies of CXCR5 suggest that it plays an essential role in B cell migration. CXCR5 expression has been reported in human blood and salivary gland and in animal lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil. ESTs (expressed sequence tags) have been isolated from human brain, germ cell, lung, lymph, and pancreas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Research studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity in GPCRs have tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which are used in mental health and allergy applications, respectively.
Spezifikation

Spezifikation

CD185 (CXCR5)
Monoclonal
5 μL/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P32302
Burkitt lymphoma receptor 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; C-X-C chemokine receptor type 5; CD185; chemokine (C-X-C motif) receptor 5; CXC Chemokine Receptor 5; CXC-R5; CXCR-5; HUMSTR; MDR-15; Monocyte-derived receptor 15
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Non-human primate, Rhesus Monkey
Flow Cytometry
MU5UBEE
Super Bright 436
CXCR5
Liquid
CXCR5
IgG2b, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
643
Videos
Dokumentation