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CD16 Mouse anti-Human, APC-H7, Clone: 3G8, BD
Mouse Monoclonal Antibody
505.00 CHF - 740.00 CHF
Spezifikation
| Antigen | CD16 |
|---|---|
| Klon | 3G8 |
| Anwendungen | Flow Cytometry |
| Klassifikation | Monoclonal |
| Konjugat | APC-H7 |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15860429
|
BD Biosciences
560715 |
50 Tests |
505.00 CHF
1 Stück |
Verfügbar ab: 16-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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|
15830009
|
BD Biosciences
560195 |
100 Tests |
740.00 CHF
1 Stück |
Verfügbar ab: 16-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
|||||
Beschreibung
The 3G8 monoclonal antibody specifically binds to the 50-65 kDa transmembrane form of the IgG Fc Receptor (Fc γRIII), a human NK cell-associated antigen. CD16 is expressed on NK cells as well as macrophages and granulocytes. Reports indicate that CD16 plays a role in signal transduction and NK cell activation. The 3G8 antibody blocks the binding of soluble immune complexes to granulocytes. The 3G8 antibody is reported (Vossebeld et al ., 1997) to increase intracellular calcium levels in human neutrophils by interacting with both Fc γRIIa and Fc γRIIIb molecules. This antibody has also been reported to induce homotypic neutrophil aggregation.
This clone also cross-reacts with a subset of peripheral blood lymphocytes and monocytes, but not granulocytes, of baboon and both rhesus and cynomologus macaque monkeys. Multi-color analysis reveals that the distribution on lymphocytes is similar to that found in human studies with the majority of CD16-positive lymphocytes being both CD3 and CD20 negative.
Spezifikation
| CD16 | |
| Flow Cytometry | |
| APC-H7 | |
| RUO | |
| Baboon, Cynomolgus, Human, Rhesus Monkey | |
| Human polymorphonuclear leukocytes | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| 3G8 | |
| Monoclonal | |
| Mouse | |
| Immunology | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| IgG1 κ | |
| Affinity Purified | |
| FcRIII; Fc-gamma RIII; FCG3; FCGR3; FCGRIII; FcγRIII; IGFR3 |
For Research Use Only.