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CD137 Ligand (4-1BB Ligand) Mouse anti-Human, PE-Cyanine7, Clone: 4H3, eBioscience™

Mouse Monoclonal Antibody

Marke:  Invitrogen 25-5906-42

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15825373

  • 336.00 CHF / 100 Stück


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von Anbieter 03-04-2019
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Beschreibung

Beschreibung

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
Spezifikation

Spezifikation

CD137 Ligand (4-1BB Ligand)
Monoclonal
5 μL/Test
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
P41273
41BBL, TNFRSF9, 4-1BBL, TNFSF9, CDw137L
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
4H3
PE-Cyanine7
TNFSF9
Liquid
TNFSF9
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
8744
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