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CD137 (4-1BB) Monoclonal Antibody (17B5), PE, eBioscience™, Invitrogen™
Syrian Hamster Monoclonal Antibody
147.00 CHF - 411.00 CHF
Spezifikation
Antigen | CD137 (4-1BB) |
---|---|
Klon | 17B5 |
Konzentration | 0.2 mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15278669
|
Affymetrix eBioscience
12-1371-81 |
50 μg |
147.00 CHF
50 Mikrogramm |
Verfügbar ab: 02-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15288669
|
Affymetrix eBioscience
12-1371-82 |
100 μg |
269.00 CHF
100 Mikrogramm |
Verfügbar ab: 02-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
|||||
15298669
|
Affymetrix eBioscience
12-1371-83 |
200 μg |
411.00 CHF
200 Mikrogramm |
Verfügbar ab: 02-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Description: The 17B5 monoclonal antibody reacts with mouse CD137, also known as 4-1BB, a member of the TNFR superfamily. CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Recent data suggests CD317 is expressed on Tregs and may play a role in their proliferation. The monoclonal antibody 17B5 has strong antagonistic effect in in vitro functional assays. Applications Reported: The 17B5 antibody has been reported for use in flow cytometric analysis. Applications Tested: The 17B5 antibody has been tested by flow cytometric analysis of activated mouse splenocytes cultures. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.Spezifikation
CD137 (4-1BB) | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9 | |
TNFRSF9 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
TNFRSF9 |
17B5 | |
Flow Cytometry | |
PE | |
Syrian Hamster | |
Mouse | |
P20334 | |
21942 | |
IgG | |
Affinity chromatography | |
Antibody |
For Research Use Only.