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CD122, APC, clone: TM-b1 (TM-beta1), eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 17-1222-82

Additional Details : Gewicht : 0.25000kg

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Artikelnummer. 15320670

  • 307.00 CHF / 100 Mikrogramm


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Beschreibung

Beschreibung

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

Description: The TM-b1 monoclonal antibody reacts with mouse CD122, the 90-110kDa interleukin-2 receptor beta chain (IL-2R beta). CD122 is expressed by NK cells and some T cells in the periphery, and is upregulated by activation. CD122 associates with CD25 and CD132 (common gamma chain) to form the high affinity IL-2 receptor. High affinity binding of IL-2 to the IL-2 receptor is inhibited by the TM-b1 antibody.Applications Reported: This TM-b1 (TM-beta1) antibody has been reported for use in flow cytometric analysis.Applications Tested: This TM-b1 (TM-beta1) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
Spezifikation

Spezifikation

CD122
Monoclonal
0.2mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P16297
CD122, IL15RB, P70-75, CD122 antigen, IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, high affinity IL-2 receptor beta subunit, high affinity IL-2 receptor subunit beta, interleukin 15 receptor, beta, interleukin-2 receptor subunit beta, p75
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow Cytometry
TM-b1 (TM-beta1)
APC
Il2rb
Liquid
Il2rb
IgG2b, kappa, kappa
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
16185
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.