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Tocris Bioscience™ BMS 536924
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Artikelnummer. 30001638
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Menge:
10 mg
Packungsgröße:
10 Milligramm
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Artikelnummer. 30001638

Marke: Tocris Bioscience™ 4774/10

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Description

Dual IR/IGF1R inhibitor

Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.
TRUSTED_SUSTAINABILITY

Identifiants chimiques

CAS 468740-43-4
Summenformel C25H26ClN5O3

Spécification

Chemischer Name oder Material BMS 536924
Menge 10 mg
Formelmasse 479.96
Reinheit >98%
Molekulargewicht 479.965
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