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ACROBiosystems Biotinylated Human TIGIT Protein, Fc,Avitag™

MALS verified

Marke:  ACROBiosystems TIT-H82F1-200UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15827787

  • 1589.03 CHF / 200 Mikrogramm


Verfügbar ab
26-05-2021
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 41.3 kDa. As a result of glycosylation, the protein migrates as 45-55 kDa under reducing (R) condition, and 85-115 kDa under no
Spezifikation

Spezifikation

NP_776160.2
HEK293
Human
41.3 kDa
200 µg
Met 22 - Pro 141
TIGIT,VSIG9,VSTM3
Precision Avi
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by SDS-PAGE
Biotinylated Human TIGIT, Fc,Avitag (MALS verified) (TIT-H82F1) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Pro 141 (Accession # Q495A1-1).
-20°C
TIGIT
Fc Tag and Avi Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation