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ACROBiosystems Biotinylated Human SCF / KITLG Protein, Avitag™,His Tag

Biotinylated Protein

437.70 CHF - 1925.89 CHF

Spezifikation

Zugriffsnummer AAH69797
Molekulargewicht 21.7 kDa
Quelle Biotinylated Human SCF, Avitag,His Tag (SCF-H82E1) is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Ala 190 (Accession # AAH69797).
Immunogen Glu 26 - Ala 190
Lagerungsbedingungen -20°C
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15837657
Unterlagen ansehen Aktionsdetails
ACROBiosystems
SCF-H82E1-25UG
25 μg
437.70 CHF
25 Mikrogramm
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Verfügbar ab: 10-04-2024
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15827657
Unterlagen ansehen Aktionsdetails
ACROBiosystems
SCF-H82E1-200UG
200 μg
1925.89 CHF
200 Mikrogramm
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Sparen Sie bis zu 
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Verfügbar ab: 10-04-2024
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Zum Warenkorb hinzufügen
 
Beschreibung

Beschreibung

Kit ligand (KITLG) is also known as stem cell factor (SCF), mast cell growth factor (MGF), steel factor (SF), which belongs to the SCF family, and is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. KITLG is the ligand for the receptor-type protein-tyrosine kinase KIT. SCF / MGF plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG / SCF binding can activate several signaling pathways. KITLG / SF Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG / SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG / SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG / SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5 - trisphosphate. KITLG / SCF acts synergistically with other cytokines, probably interleukins.

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 21.7 kDa. The protein migrates as 26-38 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Spezifikation

Spezifikation

AAH69797
Biotinylated Human SCF, Avitag,His Tag (SCF-H82E1) is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Ala 190 (Accession # AAH69797).
-20°C
SCF
Human
PBS, pH7.4
HEK293
MABSol™ Biotin Labeled Proteins
21.7 kDa
Glu 26 - Ala 190
KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL
Precision Avi
His Tag and Avi Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
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Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

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