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ACROBiosystems Biotinylated Human Fc gamma RIIA / CD32a (H167) Protein, Avitag™,His Tag (SPR & BLI verified)

Biotinylated Protein

Marke:  ACROBiosystems CDA-H82E6-200UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826347

  • 1128.43 CHF / 200 Mikrogramm


Verfügbar ab
04-06-2021
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Beschreibung

Beschreibung

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM­bearing receptors may also be coexpressed and co­engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 24.0 kDa. The protein migrates as 30-38 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>90% as determined by SDS-PAGE
Biotinylated Human CD32a (H167), Avitag,His Tag (SPR and BLI verified) (CDA-H82E6) is expressed from human 293 cells (HEK293). It contains AA Ala 36 - Ile 218 (Accession # P12318-1 (H167)).
-20°C
Fc gamma RIIA / CD32a
His Tag and Avi Tag
HEK293
Human
24.0 kDa
200 µg
Ala 36 - Ile 218
CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2
Precision Avi
PBS, pH7.4
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation