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ACROBiosystems Biotinylated Human CTLA-4 Protein, Fc, Avitag™
Biotinylated Protein
315.25 CHF - 1374.49 CHF
Spezifikation
Zugriffsnummer | NP_005205.2 |
---|---|
Molekulargewicht | 41.8 kDa |
Quelle | Biotinylated Human CTLA-4, Fc,Avitag (CT4-H82F3) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1). |
Immunogen | Ala 37 - Phe 162 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15826527
|
ACROBiosystems
CT4-H82F3-200UG |
200 μg |
1374.49 CHF
200 Mikrogramm |
Verfügbar ab: 13-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15836527
|
ACROBiosystems
CT4-H82F3-25UG |
25 μg |
315.25 CHF
25 Mikrogramm |
Verfügbar ab: 13-05-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 41.8 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_005205.2 | |
Biotinylated Human CTLA-4, Fc,Avitag (CT4-H82F3) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # P16410-1). | |
-20°C | |
CTLA-4 | |
Human | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
41.8 kDa | |
Ala 37 - Phe 162 | |
CTLA4,CD152 | |
Precision Avi | |
Fc Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by reduced SDS-PAGE |