Learn More
ACROBiosystems Biotinylated Human CD155 / PVR Protein, Fc, Avitag™
Biotinylated Protein
Marke: ACROBiosystems CD5-H82F6-200UG
Additional Details : Gewicht : 0.00001kg
Beschreibung
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 63.5 kDa. As a result of glycosylation, the protein migrates as 75-100 kDa under reducing (R) condition, and 140-180 kDa underSpezifikation
NP_006496.2 | |
200 μg | |
Trp 21 - Asn 343 | |
PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5 | |
Precision Avi | |
Fc Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
63.5 kDa | |
Biotinylated Human CD155, Fc,Avitag (CD5-H82F6) is expressed from human 293 cells (HEK293). It contains AA Trp 21 - Asn 343 (Accession # NP_006496.2). | |
-20°C | |
CD155 | |
Human | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |