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ACROBiosystems Biotinylated Human CD155 / PVR Protein, Fc, Avitag™

Biotinylated Protein

Marke:  ACROBiosystems CD5-H82F6-25UG

Additional Details : Gewicht : 0.00001kg

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Artikelnummer. 15826217

  • auf Anfrage / 25 Mikrogramm

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Beschreibung

Beschreibung

CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.

This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 63.5 kDa. As a result of glycosylation, the protein migrates as 75-100 kDa under reducing (R) condition, and 140-180 kDa under
Spezifikation

Spezifikation

NP_006496.2
HEK293
Human
63.5 kDa
25 µg
Trp 21 - Asn 343
PVR,FLJ25946,PVS,CD155,TAGE4,HVED,NECL5
Precision Avi
Tris with Glycine, Arginine and NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by SDS-PAGE
Biotinylated Human CD155, Fc,Avitag (CD5-H82F6) is expressed from human 293 cells (HEK293). It contains AA Trp 21 - Asn 343 (Accession # NP_006496.2).
-20°C
CD155
Fc Tag and Avi Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation