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beta-Catenin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 1B8A1, Proteintech

Mouse Monoclonal Antibody

Marke:  Proteintech 66379-1-IG-20UL

Additional Details : Gewicht : 0.00010kg

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Artikelnummer. 16838205

  • 131.19 CHF / 20 Mikroliter

Verfügbar ab: 28-06-2022
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Beschreibung

Beschreibung

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation.
Spezifikation

Spezifikation

beta-Catenin
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P35222, Q02248, Q9WU82
CTNNB1
Peptide
20 μL
Primary
Mouse, Rat, Human, Porcine
Liquid
Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry, Immunofluorescence
1B8A1
Unconjugated
CTNNB1
b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286
Mouse
Protein G
RUO
12387, 1499, 397657, 84353
Antibody
IgG1
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote