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beta-Catenin Antibody, Novus Biologicals™
Rabbit Polyclonal Antibody
Marke: Novus Biologicals NBP2-29476
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Beschreibung
beta-Catenin Polyclonal specifically detects beta-Catenin in Human, Mouse samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.
Spezifikation
| beta-Catenin | |
| Polyclonal | |
| Unconjugated | |
| PBS with 0.05% BSA. with 0.05% Sodium Azide | |
| beta 1 (88kD), beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923 | |
| Rabbit | |
| 92 kDa | |
| 0.1 mg | |
| Cancer, Cellular Markers, Extracellular Matrix, Neuroscience, Phospho Specific, Stem Cell Signaling Pathway, Wnt Signaling Pathway | |
| 1499 | |
| Human, Mouse | |
| Purified |
| Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation | |
| 0.2 mg/ml | |
| Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry 1-2ug/ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 1-2ug/ml | |
| P35222 | |
| CTNNB1 | |
| A synthetic peptide from the middle of beta-Catenin protein (Uniprot: P35222) | |
| Protein A purified | |
| RUO | |
| Primary | |
| Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. | |
| Store at 4C. | |
| IgG |
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