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Axl Mouse anti-Human, PE, Clone: DS7HAXL, eBioscience™

Mouse Monoclonal Antibody

Marke:  Invitrogen 12-1087-42

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15983164

  • 317.00 CHF / 100 Stück


Verfügbar ab
05-10-2020
Zum Warenkorb hinzufügen

Beschreibung

Beschreibung

Axl is a member of the TAM receptor family, which also includes also MerTK and TYRO3. Axl contains protein kinase activity and is activated by dimerization and auto-phosphorylation upon ligand binding. In response to its ligands, Protein S and GAS6, Axl activates anti-inflammatory pathways (through SOCS-1 and SOCS-3), which limits TLR and cytokine signaling. This results in dampened inflammatory responses in macrophages and DCs. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.
Spezifikation

Spezifikation

Axl
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P30530
ARK; AXL; JTK11; Tyro7; UFO
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
DS7HAXL
PE
AXL
Liquid
AXL
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
558
Videos
Dokumentation