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Invitrogen™ AXIN1 Monoclonal Antibody (K.53.7)
Rabbit Monoclonal Antibody
Marke: Invitrogen™ MA514854
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Beschreibung
It is not recommended to aliquot this antibody.
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
Spezifikation
| AXIN1 | |
| Monoclonal | |
| 40 μg/mL | |
| 0.01M HEPES with 50% glycerol, 100 μg/mL BSA, 0.15M NaCl and <0.02% sodium azide, pH 7.5 | |
| O15169, O35625, O70239 | |
| AXIN1 | |
| Recombinant human Axin1. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| K.53.7 | |
| Unconjugated | |
| AXIN1 | |
| AI316800; AXIN; axin 1; Axin1; axin-1; Axis inhibition protein 1; axis inhibitor 1; Fu; fused; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; Kb; Ki; kinky; knobbly; LA16c-314G4.3; MGC52315; PPP1R49; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 12005, 79257, 8312 | |
| -20°C | |
| Liquid |
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