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Stat4 (pY693) Mouse, PE, Clone: 38/P-STAT4, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 558249

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15829258

  • 440.00 CHF / 1 Stück


Verfügbar ab
27-05-2021
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Beschreibung

Beschreibung

The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNγ in response to treatment with IL-12. IFNγ plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.

Intracellular Staining

Spezifikation

Spezifikation

Stat4 (pY693)
38/P-STAT4
Signal transducer and activator of transcription 4; SLEB11
Affinity Purified
Phosphorylated Human Stat4 (pY693)
50 Tests
Cell Biology
Primary
Human, Murine
Flow Cytometry
PE
Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide.
Murine
IgG2b, κ
RUO
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.