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Stat1 (pY701) Mouse, Alexa Fluor 647, Clone: 4A, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 562070

Additional Details : Gewicht : 0.01000kg

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Artikelnummer. 15831619

  • 1340.00 CHF / 1 Stück


Verfügbar ab
03-06-2021
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Beschreibung

Beschreibung

Stat ( S ignal t ransducer and a ctivators of nterferon- S timulated G ene F actor 3 ) complex, which is the primary transcription activator induced by the binding of the interferon to a specific cell-surface receptor. Stat1 has two alternatively spliced isoforms, 91-kDa Stat1α and 84-kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, or CSF-1 to their respective receptors, the Stat1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. This results in the formation of an active complex that includes the DNA-binding p48 subunit. This complex is responsible for modulating the transcription of the interferon-stimulated genes (ISGs).

The 4a monoclonal antibody recognizes the phosphorylated Y701 in Stat1 α .

Spezifikation

Spezifikation

Stat1 (pY701)
4a
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Murine
IgG2a
RUO
Primary
Human, Murine
Flow Cytometry
Alexa Fluor 647
Affinity Purified
Phosphorylated Human Stat1 Peptide
250 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.