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SSEA-1 Mouse, PE, Clone: MC480, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 560886
Additional Details : Gewicht : 0.01000kg
Beschreibung
The MC480 monoclonal antibody reacts with Stage-Specific Embryonic A ntigen-1 (SSEA-1), which is a terminal carbohydrate epitope (3-fucosyl-N-acetyllactosamine or 3-FAL) on glycoproteins and lactose series glycolipids. SSEA-1 is related to Lewis blood group antigens and is found in a variety of embryonic and adult tissues and cancers. As its name implies, the expression of SSEA-1 is stage-specific and can be used to characterize embryonic cells and monitor their differentiation. However, its expression pattern differs in the human and mouse. In the human, SSEA-1 is not found on embryonic stem (ES) cells, embryonic inner cell mass (ICM), or teratocarcinoma (embryonal carcinoma or EC) cells. As human EC and ES cells undergo differentiation, SSEA-1 expression is upregulated. In the adult, the same epitope is expressed as CD15 on granulocytes and monocytes, but not lymphocytes or dendritic cells. In the mouse, SSEA-1 is found on EC, ES, and primordial germ cells, 8-cell to blastocyst embryos, ICM, and on subpopulations of cells in the adult central nervous system, including stem cells. In contrast to the human, SSEA-1 expression is reduced as mouse EC and ES cells undergo differentiation.
Spezifikation
| SSEA-1 | |
| Monoclonal | |
| PE | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Mouse Teratocarcinoma Cell Line | |
| 25 Tests | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| MC480 | |
| 3-FAL, X-hapten, LeX antigen, CD15 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgM κ |
For Research Use Only.